2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide, dihydrochloride salt
CAS: 912445-05-7
Molecular Formula: C13H16N4O
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride - Names and Identifiers
| Name | 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide, dihydrochloride salt |
| Synonyms | Abt-888 ABT-888 ABT888 HCl ABT-888.2HCl Veliparib 2HCl Veliparib hydrochloride ABT-888 dihydrochloride Veliparib dihydrochloride ABT-888(Veliparib dihydrochloride) 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide,dihydrochloridesalt 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-carboxamide, dihydrochloride salt |
| CAS | 912445-05-7 |
| EINECS | 1592732-453-0 |
| InChI | InChI=1/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1 |
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride - Physico-chemical Properties
| Molecular Formula | C13H16N4O |
| Molar Mass | 244.296 |
| Melting Point | >173°C (dec.) |
| Solubility | Methanol (Slightly, Heated), THF (Slightly, Heated) |
| Appearance | Colorless to white crystalline solid. |
| Color | Off-White to Dark Yellow |
| Storage Condition | Refrigerator |
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.152 ml | 15.762 ml | 31.525 ml |
| 5 mM | 0.63 ml | 3.152 ml | 6.305 ml |
| 10 mM | 0.315 ml | 1.576 ml | 3.152 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide dihydrochloride - Reference Information
| Overview | veliparib hydrochloride (ABT-888) is an orally effective PARP1/2 inhibitor developed by AbbVie. It was first introduced into clinical practice in 2007. so far, 90 clinical studies have been carried out, including triple negative breast cancer, non-small cell lung cancer, ovarian cancer, melanoma, brain cancer and so on. ABT-888, it was used in combination with DNA-damaging chemotherapeutic drugs to treat glioblastoma multiforme, epithelial ovarian cancer and metastatic brain cancer, and received FDA Orphan Drug Designation in 2008, 2009and 2014 respectively. |
| properties | ABT-888 the biggest difference from other PARP inhibitors is that, ABT-888 in combination with chemotherapy drugs in the treatment of tumor in patients with no genotyping, and ABT-888,BMN-673, rekappab et al. were the first to BRCA mutation of tumor patients. Apart from chemotherapy, triple negative breast cancer currently does not have a good targeted therapy, ABT-888 if successful, will be very good to meet the clinical gap. |
| pharmacodynamics | According to the results of the study published by AbbVie, ABT-888 was absorbed faster, the peak time (Tmax) of blood drug concentration was 1.2-2.5h;Cmax/AUC increased linearly with the increase of dose, however, the drug has a short half-life of plasma concentration (t1/2=6h) and is rapidly eliminated in vivo, which makes it difficult to maintain the drug concentration required for effective PARP enzyme activity inhibition for a long time, in clinical practice, it is necessary to administer large doses more than twice a day (dosa alone> 400mg/time). |
| Use | velipani Dihydrochloride is a poly (ADP-ribose) polymerase (PARP)-1 and -2 inhibitors with Chemical sensitization and antitumor activity. |
Last Update：2024-04-09 20:52:54
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CAS: 912445-05-7
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CAS: 912445-05-7
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Mobile: 18021002903
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